Pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves

نویسندگان

  • D. Ram Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India
  • H. S. Sandhu Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India
  • S. K. Sharma Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India
  • V. K. Dumka Department of Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, India
چکیده مقاله:

The pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. Peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above MIC90  in plasma was detected up to 12 h of administration. The bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1.5%. High values of AUC (8.81 ± 0.37μg.h/ml) and Vdarea (1.06 ± 0.04 L/kg) reflected a vast area of body covered by drug concentration and appropriate penetration of levofloxacin into various body fluids and tissues. The elimination half-life and mean residence time were 3.27 ± 0.31 h and 5.4 ± 0.59 h, respectively. The total body clearance was 343.2 ± 14.1 ml/kg/h. An appropriate intramuscular dosage regimen for levofloxacin in buffalo calves would be 1.7 mg/kg repeated at 12-h intervals.    

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pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves

the pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above mic90  in plasma was detected up to 12 h of administration. the bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....

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عنوان ژورنال

دوره 9  شماره 2

صفحات  121- 126

تاریخ انتشار 2008-06-20

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